Evaluation of the effectiveness of sodium hyaluronate, sesame oil, honey, and silver nanoparticles in preventing postoperative surgical adhesion formation. An experimental study

Abstract Purpose: To evaluate the effectiveness of sodium hyaluronate, sesame oil, honey, and silver nanoparticles in preventing of postoperative surgical adhesion formation. Methods: Forty male Wistar rats were randomly assigned into five groups with eight rats in each group including control, hyaluronate, sesame, honey and silver groups. After two weeks the animals underwent laparotomy and were evaluated by two different blinded surgeons for severity of adhesions based on the two different classification scoring systems including Nair classification and cumulative adhesion scoring scale. Results: The scores of severity of adhesions in the hyaluronate and sesame groups were significantly lower than the control group based on the Nair classification (both P-values = 0.02), however based on the cumulative adhesion scoring scale just the score of severity of adhesions in the hyaluronate group was significantly lower than the control group (P-value = 0.02). In the hyaluronate group the severity of adhesions was decreased by 48% based on the cumulative adhesion scoring scale. Conclusions: Sodium hyaluronate and sesame oil may have a significant effect in preventing postoperative surgical adhesion formation.

The Evaluation of Laparoscopic Orchiopexy on the Treatment of Non-palpable Undescended Testes .

Objectives: Cryptorchidism is the most frequent birth anomaly in boys with 2-5% prevalence in full term infants. This anomaly is associated with an increased risk of testicular cancer and infertility as well as hernia, testicular torsion, and psychological distress. Surgery is the main treatment for this anomaly. This study aimed to evaluate the therapeutic efficacy of laparoscopic orchiopexy in the treatment of non-palpable undescended testis. Methods: Forty patients with a non-palpable testis were evaluated by laparoscopic orchiopexy in a hospital in Hamedan city, Iran, during 2006 to 2009. The average age of patients was 19±12.16 months old. The patients were followed up after the surgery and three months later to assess the response to treatment and the testicular atrophy. Results: Thirteen patients did not have a testis in the laparoscopic investigation and six patients had testis located in the inguinal canal. So they were excluded from the analysis. Seventeen patients were treated by one-staged laparoscopic orchiopexy while four patients were treated by two-staged Fowler-Stephens laparoscopic orchiopexy. The success rate for the treatment was 100%. Conclusion: Laparoscopic orchiopexy is a safe and effective method for the treatment of non-palpable undescended testis.